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1994-09-24
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Document 0641
DOCN M9490641
TI Epidemiology of genital herpes.
DT 9411
AU Kinghorn GR; Department of Genitourinary Medicine, Royal Hallamshire
Hospital,; Sheffield, UK.
SO J Int Med Res. 1994;22 Suppl 1:14A-23A. Unique Identifier : AIDSLINE
MED/94341479
AB New serological methods, based on the detection of type-specific
antibodies to herpes simplex virus (HSV) glycoproteins, have allowed a
reappraisal of the prevalence of genital herpes. During the 1980s,
genital herpes continued to be an infection of epidemic proportions in
many developed countries. In the USA, although there was evidence of a
decline in the age-specific prevalence of HSV type 1 (HSV-1) infection,
the seroprevalence of HSV type 2 (HSV-2) has continued to increase.
Among those attending sexually transmitted disease clinics in the USA,
30-50% of adults now have antibodies to HSV-2. Only a minority of HSV-2
infected persons present with clinical disease related to this
infection. In some countries, an increase in the incidence of severe
primary genital infections caused by HSV-1, which often occur in
monogamous relationships, has been reported. Genital ulcer disease, of
which genital herpes is the most common cause in developed countries, is
an important risk factor for the acquisition and transmission of human
immunodeficiency virus (HIV) infection. Furthermore, evidence is
accruing for a potential role of HSV reactivation in the progression of
immune deficiency in HIV-infected individuals.
DE Adult Age Factors England/EPIDEMIOLOGY Female Herpes
Genitalis/COMPLICATIONS/*EPIDEMIOLOGY/TRANSMISSION Herpesvirus 1, Human
Herpesvirus 2, Human Human HIV Infections/COMPLICATIONS Male
Recurrence Sweden/EPIDEMIOLOGY United States/EPIDEMIOLOGY Virus
Shedding JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).